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PREZISTA® Side Effects

PREZISTA® Side Effects

What are the possible side effects of PREZISTA®?

It’s important to understand the possible side effects you may experience when taking PREZISTA® (darunavir) with other HIV medicines. Your healthcare provider may help you manage some of the side effects that you may experience. Some side effects are more serious than others.

  • PREZISTA® can interact with other medicines and cause serious side effects. See "Who should not take PREZISTA®?"
  • PREZISTA® may cause liver problems. Some people taking PREZISTA®, together with Norvir® (ritonavir), have developed liver problems which may be life-threatening. Your healthcare provider should do blood tests before and during your combination treatment with PREZISTA®. If you have chronic hepatitis B or C infection, your healthcare provider should check your blood tests more often because you have an increased chance of developing liver problems
  • Tell your healthcare provider if you have any of these signs and symptoms of liver problems: dark (tea-colored) urine, yellowing of your skin or whites of your eyes, pale-colored stools (bowel movements), nausea, vomiting, pain or tenderness on your right side below your ribs, or loss of appetite
  • PREZISTA® may cause a severe or life-threatening skin reaction or rash. Sometimes these skin reactions and skin rashes can become severe and require treatment in a hospital. You should call your healthcare provider immediately if you develop a rash. However, stop taking PREZISTA® and ritonavir combination treatment and call your healthcare provider immediately if you develop any skin changes with these symptoms: fever, tiredness, muscle or joint pain, blisters or skin lesions, mouth sores or ulcers, red or inflamed eyes, like “pink eye.” Rash occurred more often in people taking PREZISTA® and raltegravir together than with either drug separately, but was generally mild

The most common side effects related to taking PREZISTA® include diarrhea, nausea, rash, headache, stomach pain, and vomiting. Other important severe side effects include inflammation of the liver or pancreas and increased blood fat levels, diabetes, and changes in body fat.

Other possible side effects of Protease Inhibitors (PIs), including PREZISTA®

Some other side effects sometimes seen in patients taking PIs, including PREZISTA®, are:

  • High blood sugar, diabetes, or worsening of diabetes
  • More bleeding in people with hemophilia
  • Changes in body fat
    • The exact cause and long-term health effects of these conditions are not known.
  • Changes in your immune system
    • Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time.