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Taking PREZISTA® with other medicines

Tell your Healthcare Provider about all the medicines you take.

PREZISTA® (darunavir) may interact with other medicines. This means that taking PREZISTA® with certain medicines could cause serious and/or life-threatening side effects or may result in the loss of its effectiveness. Do not take PREZISTA® if you are taking the following medicines:

  • Alfuzosin (Uroxatral®)
  • Apixaban (Eliquis®)
  • Avanafil (Stendra®)
  • Boceprevir (Victrelis®)
  • Cisapride (Propulsid®)
  • Colchicine (Colcrys®, Col-Probenecid®) if you have liver or kidney problems
  • Dabigatran etexilate (Pradaxa®) in specific renal impairment groups
  • Dihydroergotamine (D.H.E.45®, Embolex®, Migranal®)
  • Dronedarone (Multaq®)
  • Ergotamine (Cafergot®, Ergomar®)
  • Everolimus (Zortress®, Afinitor®)
  • Indinavir (Crixivan®)
  • Lopinavir/ritonavir (Kaletra®)
  • Lovastatin (Mevacor®, Altoprev®, Advicor®)
  • Methylergonovine
  • Oral midazolam (Versed®)
  • Pimozide (Orap®)
  • Ranolazine (Ranexa®)
  • Rifampin (Rifadin®, Rifater®, Rifamate®, Rimactane®)
  • Rifapentine (Priftin®)
  • Rivaroxaban (Xarelto®)
  • Saquinavir (Invirase®)
  • Salmeterol (Advair®, Serevent®)
  • Sildenafil (Revatio®) only when used to treat pulmonary arterial hypertension
  • Simeprevir (Olysio®)
  • Simvastatin (Zocor®, Simcor®, Vytorin®)
  • The herbal supplement or products containing St. John's Wort ( Hypericum perforatum)
  • Telaprevir (Incivek®)
  • Triazolam (Halcion®)
  • Voriconazole (VFend®)

All trademarks are the property of their respective owners.

Serious problems can happen if you or your child takes any of these medicines with PREZISTA®

Before taking PREZISTA®, tell your healthcare provider if you are taking sildenafil (Viagra®, Revatio®), vardenafil (Levitra®, Staxyn®), tadalafil (Cialis®, Adcirca®), atorvastatin (Lipitor®), rosuvastatin (Crestor®), or pravastatin (Pravachol®).

This is not a complete list of medicines that you should tell your healthcare provider about. It may be helpful to keep a list of all the medicines you take. Show this list to all of your healthcare provider and pharmacists any time you get a new medicine. They can tell you if these other medicines can be taken with PREZISTA®. Please see Full Product Information for more details.

You must tell your healthcare provider about any other prescription medicines you take, and any nonprescription medicines, vitamins and herbal supplements you take.

Tell your healthcare provider if you are taking estrogen-based contraceptives (birth control). PREZISTA® might reduce the effectiveness of estrogen-based contraceptives. You must take additional precautions for birth control, such as condoms.

Do not stop taking PREZISTA® or any other medicines without first talking with your healthcare provider.